I am interested in function and regulation of adipose tissue in aging and age-related disease. Aging is associated with redistribution of body fat with loss of subcutaneous fat and gain of visceral fat, which leads to increased risk of metabolic syndrome and cardiovascular disease (CVD). Accumulation of senescent cells in fat with aging induces the releasing of inflammatory cytokines and chemokines. I am particularly interested in elucidating the mechanisms of how preadipocytes and adipocytes in aging manipulate the function of vasculature. I am also interested in obesity induced cellular senescence, which links to the dysfunction of adipose tissue and metabolic disorder.
Tracy Crotty, Jinjin Cai, Fumio Sakane, Akinobu Taketomi, Stephen M. Prescott, and Matthew K. Topham. Diacylglycerol kinase δ regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A. 2006 103(42):15485-15490
Jinjin Cai, Hanan Abramovicid, Stephen H. Geed, and Matthew K. Topham. Diacylglycerol kinases as sources of phosphatidic acid. Biochim Biophys Acta., 2009 Sep;1791(9):942-8
Jinjin Cai, Tracy Crotty, Ethan Reichert, Kermit Carraway, Diana Stafforini, and Matthew Topham. Diacylglycerol kinase delta and protein kinase C alpha modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8. J Biol Chem. 2010 Mar 5;285(10):6952-9
Philomena Alapatt, Fangjian Guo, Susan M. Komanetsky, shuping wang, Jinjin Cai, Ashot Sargsyan, Eduardo Rodriguez Diaz, Brandon Bacon, Pratik Aryal, and Timothy E. Graham. Liver retinol transporter and receptor for serum retinol binding protein (RBP4). J Biol Chem 2013 Jan 11;288(2):1250-65
Sargsyan A, Jinjin Cai , Fandino LB, Labasky ME, Forostyan T, Colosimo LK, Thompson SJ, Graham TE. Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor. Sci Report. 2015 Jul 28;5:12397
Thompson SJ, Sargsyan A, Lee SA, Yuen JJ, Jinjin Cai , Smalling R, Ghyselinck N, Mark M, Blaner WS, Graham TE.Hepatocytes are the Principal Source of Circulating RBP4 in Mice. Diabetes. 2016