Click here for Dr. Trott’s CV
I am interested in the integrative physiology of vascular function in health and disease. Specifically, I am interested in how the immune system, adipose tissue and blood vessels interact to mediate vascular dysfunction with hypertension, aging and metabolic abnormalities. I am also interested in how physical activity influences these systems to promote vascular health.
Trott DW, Thabet SR, Kirabo A, Saleh M, Itani H, Norlander AE Wu J, Goldstein A, Arendshorst WJ, Madhur MS, Chen W, Li CI, Shyr Y, Harrison DG. Oligoclonal CD8+ T cells play a critical role in the development of hypertension. Hypertension In press.
Kirabo A, Fontana V, de Faria APC, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Loprena R, Xiao L, Chen W, Saleh MA, Trott DW, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Davies SS, Roberts II LJ, Moreno H, Harrison DG. Superoxide and Isoketals Activate T Cells and Promote Hypertension. J Clin Invest 124(10):4642-56, 2014.
Trott DW, Harrison DG. The Immune System in Hypertension. Adv Physiol Ed 38(1):20-24, 2014.
Wu J, Thabet SR, Kirabo A, Trott DW, Goldstein AE, Madhur MS, Chen W, Harrison DG. Mechanisms of Aortic Stiffening in Hypertension. Circ Res 14:616-625, 2014.
Trott DW, Luttrell MJ, Seawright JW, Woodman CR. Aging impairs PI3K/Akt signaling and NO-mediated dilation in soleus muscle feed arteries. Eur J Appl Physiol 113: 2039-46, 2013.
Trott DW, Seawright JW, Luttrell MJ, Woodman CR. NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries. J Appl Physiol 110:1171-1180, 2011.
Trott DW and Seawright JW. Rethinking the role of superoxide in the ageing skeletal muscle vasculature. J Physiol 588:397-398, 2010.
Trott DW, Gunduz F, Laughlin MH, Woodman CR. Exercise training reverses age-related decrements in endothelium-dependent dilation in skeletal muscle feed arteries. J Appl Physiol 109:1925-34, 2009.
Woodman CR, Trott DW, Laughlin MH. Short-term increases in intraluminal pressure reverse age-related decrements in endothelium-dependent vasodilation in soleus muscle feed arteries. J Appl Physiol, 103:1172-1179, 2007.