AJDAssociate Professor, Department of Internal Medicine, Division of Geriatrics
Adjunct Associate Professor, Departments of Biochemistry and Nutrition and Integrative Physiology

Click Here for Dr. Donato’s CV

Office Address:

VA Med.Center, SLC
GRECC Bldg 2 Rm 2D15A
500 Foothill Drive
Salt Lake City, UT 84148
Office  801-582-1565 Ext 4237
Lab      801-582-1565 Ext 4331
Cell     619-701-1744
Email: Tony.Donato@utah.edu

Research Interests:

My primary research focus is vascular aging, in particular the cellular, molecular and tissue specific events that induce reductions in muscle blood flow during exercise, impair arterial endothelial function and stiffen large elastic arteries in older rodents/adults. These vascular phenotypes contribute to the age-related decline in functional capacity and the development of cardiovascular disease. My secondary focus, is to elucidate the cellular pathways which confer the vaso-protective effects of these lifestyle interventions and try to activate these pathways pharmacologically to see if this will confer some of the same benefits. I have used human, rodent, and cell models to address these questions and utilized a wide range of contemporary translational experimental techniques from microRNA gene expression to ultrasonography to investigate the aforementioned interests.

Selected Publications:

Morgan RG, Ives SJ, Lesniewski LA, Cawthon RM, Andtbacka RH, Noyes RD, Richardson RS, Donato AJ(2013). Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries. Am J Physiol Heart Circ Physiol, 305(2), H251-8.
Donato AJ, Walker AE, Magerko KA, Bramwell RC, Black AD, Henson GD, Lawson BR, Lesniewski LA, Seals DR (2013). Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell, 12(5), 772-83.
Gano LB, Donato AJ, Pasha HM, Hearon CM Jr, Sindler AL, Seals DR (2014). The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice. Am J Physiol Heart Circ Physiol, 307(12), H1754-63.
Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY (2015). Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Circulation,131(3), 289-99.
Walker AE, Henson GD, Reihl KD, Morgan RG, Dobson PS, Nielson EI, Ling J, Mecham RP, Li DY, Lesniewski LA, Donato AJ (2015). Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness. J Physiol, 593(8), 1931-43.
Frech T, Walker AE, Barrett-O’Keefe Z, Hopkins PN, Richardson RS, Wray DW, Donato AJ (2015). Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction. Clin Rheumatol, 34(5), 905-13.
Walker AE, Morgan RG, Ives SJ, Cawthon RM, Andtbacka RH, Noyes D, Lesniewski LA, Richardson RS,Donato AJ (2016). Age-related arterial telomere uncapping and senescence is greater in women compared with men. Exp Gerontol, 73, 65-71.
Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ,Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD (2016). Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res, 118(5), 856-66.