Department of Internal Medicine
University of Utah
Salt Lake City, Utah
VA Med. Center, SLC
GRECC building 2 Rm 2D20
500 Foothill Drive
Salt Lake City, UT-84148
The low grade pro-inflammation that accompanies advancing age causes arterial wall thickening and stiffening. Senescent cells showed an altered secretome profile termed the senescence-associated secretory phenotype (SASP), which may contribute to the inflammation. My primary interest is exploring the mechanism in the age-related arterial remodeling and endothelial dysfunction, especially the relationship between the telomere uncapping and SASP in endothelial cell as well as vascular smooth muscle cells during aging. I am also interested in how the telomere function impact the homeostasis of vascular system.
Liu Q, Li A, Tian Y, Wu JD, Liu Y, Li T, Chen Y, Han X, Wu K. The CXCL8-CXCR1/2 pathways in cancer. Cytokine Growth Factor Rev. 2016; 31:61-71.
Liu Y, Zhou R, Yuan X, Han N, Zhou S, Xu H, Guo M, Yu S, Zhang C, Yin T and Wu K. DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling. Oncotarget. 2015; 6(11): 8621-8634.
Liu Y, Han N, Zhou S, Zhou R, Yuan X, Xu H, Zhang C, Yin T and Wu K. The DACH/EYA/SIX gene network and its role in tumor initiation and progression. Int J Cancer. 2016;138(5):1067-1075.
Kong D, Liu Y, Liu Q, Han N, Zhang C, Pestell RG, Wu G and Wu K. The Retinal Determination Gene Network: From developmental regulator to cancer therapeutic target. Oncotarget. 2016; 7(31):50755-50765
Liu Q, Li A, Tian Y, Liu Y, Li T, Zhang C, Wu JD, Han X, Wu K. The expression profile and clinic significance of the SIX family in non-small cell lung cancer. J Hematol Oncol. 2016; 9(1):119
Liu Y, Yin TJ, Zhou R, Zhou S, Fan L and Zhang RG. Expression of thymidylate synthase predicts clinical outcomes of pemetrexed-containing chemotherapy for non-small-cell lung cancer: a systemic review and meta-analysis. Cancer Chemother Pharmacol. 2013; 72(5): 1125-1132.