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My research focuses on cardiovascular physiology and the influence of aging and lifestyle on the development of cardiovascular disease. There are a number of age- and lifestyle-related changes in the structural and functional properties of arteries that result in impaired vascular function, elevated blood pressure, and contribute to cardiovascular disease risk. I study the effects of intervention, particularly exercise and dietary, on restoration of vascular function and reductions in blood pressure. Additionally, I study physiological and molecular mechanisms responsible for changes in vascular function and blood pressure with aging and following intervention.
Kraus AS, Pasha P, Machin DR, Alkatan M, Kloner RA, Tanaka H. Bilateral upper limb remote ischemic preconditioning improves peak anaerobic power. Medicine and Science in Sports and Exercise. In review.
Machin DR, Christmas KM, Chou TH, Hill S, Van Pelt D, Trombold JR, Coyle EF. Dose response effects of pomegranate juice supplementation after eccentric exercise. Journal of Sports Sciences. In review.Machin DR, Park W, Alkatan M, Mouton M, Tanaka H. Effects of non-fat dairy products added to the routine diet on vascular function. Journal of the American College of Cardiology. In review.
Machin DR, Park W, Alkatan M, Mouton M, Tanaka H. Hypotensive effects of solitary addition of conventional nonfat dairy products to the routine diet: a randomized controlled trial. American Journal of Clinical Nutrition. Accepted.
Trombold JR, Christmas KM, Machin DR, Van Pelt D, Chou TH, Kim IY, Coyle EF. Postexercise macronutrient intake and subsequent postprandial triglyceride metabolism. Medicine and Science in Sports and Exercise. Published ahead-of-print.
Trombold JR, Christmas KM, Machin DR, Kim IY, Coyle IY. Acute high-intensity endurance exercise is more effective than moderate-intensity exercise for attenuation of postprandial triglyceride elevation. Journal of Applied Physiology. 114(6): 792-800, 2013.
Vavrek J, Machin DR, Tanaka H. Progression of athletic performance in age-group swimmers in the past 50 years. International Journal of Sports Physiology and Performance. 12(3): 608-613, 2012.
Machin DR, Tanaka H. Cross-training: crossroads to pathways in prevention of chronic diseases. Journal of Gerontology and Geriatric Research 1(2): e103, 2012.