Fellows
Venkateswara Reddy Gogulamudi
Email: gvrmicro@gmail.com
Research Interests:
My research interests are in physiological changes of cardiorenal immune responses in health and the disease states of hypertension, diabetes, atherosclerosis and obesity. In particular, I am interested in signal transduction pathways and their influence on development of pathophysiological changes. I am also interested in in-vitro, in-vivo models of age-related vascular dysfunction and its consequences at functional and molecular aspects.
Selected Publications:
Sehgal R, Gogulamudi V Reddy, Jaco J. Verweij, Atluri V. Subba Rao. Prevalence of intestinal parasitic infections among school children and pregnant women in a low socio-economic area, Chandigarh, North India. Reviews in Infection 1:100-103, 2010
Surya Prakash Dwivedi, Nuzhat Husain, Gogulamudi V Reddy. Computational Characterization of Surface-Associated Binding Interaction of Alpha-Enolase of Trichomonas vaginalis with Human Plasminogen. Human Parasitic Diseases, 3: 1–10, 2011
Donfack J. Hubert,Nkenfou Celine, Boampong N. Johnson, Ngueguim T. Florence, Ngadjui T. Bonaventure, Isha Gupta, Gogulamudi V Reddy, Inder P. Singh and Rakesh Sehgal. Ethnopharmacological Investigation and In vitro Anti-giardial Activity of Some Cameroonian Medicinal Plants. Pharmacologia, 3: 672-678, 2012
Donfack J. Hubert, Nkenfou Céline, Noubom Michel, Gogulamudi V Reddy, Ngueguim T. Florence, Boampong N. Johnson, N gadjui T. Bonaventure, Inder P. Singh, Rakesh Sehgal. In vitro leishmanicidal activity of some Cameroonian medicinal plants. Experimental Parasitology. 134: 304-308, 2013
Gogulamudi V Reddy, D. Kaul, M L Dubey, R Sehgal. Downregulation of host tryptophan-aspartate containing coat (TACO) gene restricts the entry and survival of Leishmania donovani in human macrophage model. Microbiol.,13: 946, 2015
Gonzalez AA,Liu L, Lara LS, Bourgeois CR, Ibaceta-Gonzalez C, Salinas-Parra N, Gogulamudi V Reddy, Seth DM, Prieto MC. PKCα-dependent augmentation of cAMP and CREB phosphorylation mediates the angiotensin II stimulation of renin in the collecting duct. Am J Physiol Renal Physiol., 12: 2015
ADELOLA ADEYEMO
Email: Lola.Adeyemo@utah.edu
Research Interests:
My research interests center on the impact of cardiovascular diseases (CVD) and associated conditions such as hypertension and diabetes, as well as assessing how diet and physical activity can influence CVD etiology and vascular function. After receiving my Bachelor’s and Master’s Degrees in Exercise Physiology, my Doctoral studies examined the cellular mechanisms underlying racial differences in endothelial dysfunction in order to gain insight into the health disparities and outcomes seen in the wider population.
As a Postdoctoral fellow in the TVPL my training and work explores the pathways and mechanisms involved in common age-associated vascular conditions. Incorporating rodent, cell culture, and human models, I examine the role of shear stress and atherosclerosis on the endothelium, and T cells in the arterial dysfunction seen with advancing age.
Selected Publications:
Trott DW, Machin DR, Phuong TTT, Adeyemo AO, Bloom SI, Bramwell RC, Sorensen ES, Lesniewski LA, Donato AJ. T cells mediate cell non-autonomous arterial ageing in mice. J Physiol. 2021 Aug;599(16):3973-3991. doi: 10.1113/JP281698. PMID: 34164826; PMCID: PMC8425389.
Cook MD, Ling C, Grimm H, Adeyemo A, Aldokhayyil M, Heffernan K, Fernhall B, Brown M. Primary African American Endothelial Cells Exhibit Endothelial Dysfunction with an Exacerbated Inflammatory Profile and Blunted MMP-2 Activity. Artery Research. 2021 Mar 1;27(1):38-46. doi.org/10.2991/artres.k.201102.005
Cook, MD, Anderson, L, Aldokhayyil, M, Adeyemo, A, Guinyard, M, Brown, M. (2019). Endothelial Dysfunction and Hypertension in African Americans: Overview of the Role of the Gut Microbiome. American Journal of Hypertension Research, 6(1), 1-7. doi: 10.12691/ajhr-6-1-1
jISOK LIM
Email: jslim4599@gmail.com
Research Interests:
My research interest is to understand the physiological and molecular mechanisms responsible for age-related development of cardiovascular disease. As functional and structural alterations in arteries are the main culprit of increase cardiovascular risks, it is crucial to elucidate the cellular pathways in the progression of arterial aging. In addition, my research focus lies on treatment and prevention strategy to mitigate arterial dysfunction with advancing age.
Selected Publications:
Hwang CL, Lim J, Yoo JK, Kim HK, Hwang MH, Handberg EM, Petersen JW, Holmer BJ, Leey Casella JA, Cusi K, Christou DD. Effect of all-extremity high-intensity interval training vs. moderate-intensity continuous training on aerobic fitness in middle-aged and older adults with type 2 diabetes: A randomized controlled trial. Exp Gerontol. 2019 Feb;116:46-53.
Leary MP, Lim J, Park W, Ferrari R, Eaves J, Roy SJ, Machin DR, Tanaka H. Non-fat milk attenuates acute hypertriglyceridemia in obese individuals who consume a high fat diet: A randomized control trial. Journal of Nutrition & Intermediary Metabolism. 2018 May; 12:8-13.
Yoo JK, Pinto MM, Kim HK, Hwang CL, Lim J, Handberg EM, Christou DD. Sex impacts the flow-mediated dilation response to acute aerobic exercise in older adults. Exp Gerontol. 2017 May;91:57-63.
Lim J, Pearman ME, Park W, Alkatan M, Machin DR, Tanaka H. Impact of blood pressure perturbations on arterial stiffness. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1540-5.
arthur josé pontes oliveira de almeida
Email: arthur-jp@hotmail.com
Research Interests:
My research interest is to understand how the biology of aging affects vascular function and enhances susceptibility to diseases, especially cardiovascular diseases. Particularly, how endothelial cells, the internal monolayer of blood vessels, contribute to these harmful conditions. In addition, in understanding aging itself through elucidating the molecular signaling that controls cell fate (e.g. apoptosis, senescence, differentiation) and how this could drive dysfunction over time. Lastly, seeking molecules that could target these mechanisms aiming to prevent or treat age-related vascular dysfunction.
Selected Publications:
de Almeida Feitosa MS, de Almeida AJPO, Dantas SH, de Lourdes Assunção Araújo de Azevedo F, de Souza Júnior JF, Gonçalves TAF, de Lima Silva S, Soares EMC, Alves HF, Lima TT, da Silva Pontes LV, Guerra RR, Araújo IGA, de Medeiros IA. Carvacrol prevents D-( +)-galactose-induced aging-associated erectile dysfunction by improving endothelial dysfunction and oxidative stress in rats. Naunyn Schmiedebergs Arch Pharmacol. 2024. DOI: 10.1007/s00210-024-03264-8
de Almeida AJPO, de Oliveira JCPL, da Silva Pontes LV, de Souza Júnior JF, Gonçalves TAF, Dantas SH, de Almeida Feitosa MS, Silva AO, de Medeiros IA. ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways. Oxid Med Cell Longev. 2022.DOI: 10.1155/2022/1225578
de Almeida AJPO, de Almeida Rezende MS, Dantas SH, de Lima Silva S, de Oliveira JCPL, de Lourdes Assunção Araújo de Azevedo F, Alves RMFR, de Menezes GMS, Dos Santos PF, Gonçalves TAF, Schini-Kerth VB, de Medeiros IA. Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases. Oxid Med Cell Longev. 2020. DOI: 10.1155/2020/1954398
de Almeida AJPO, Ribeiro T.P., de Medeiros I.A. Aging: Molecular Pathways and Implications on the Cardiovascular System. Oxid Med Cell Longev. 2017. DOI: 10.1155/2017/7941563
Kiana Schulze
Email: Kiana.schulze7@gmail.com
Research Interests:
My research interest is
Selected Publications:
Schulze, K.M., Horn, A.G., Weber, R.E., Kenney, N.J., Hageman, K.S., Behnke, B.J., Poole, D.C., and Musch, T.I., 2024. Skeletal and respiratory muscle blood flow redistribution during submaximal exercise in pulmonary hypertensive rats. The Journal of Physiology. In Press.
Schulze, K.M., Horn, A.G., Muller-Delp, J.M., White, Z.J., Hall, S.E., Medarev, S.L., Weber, R.E., Poole, D.C., Musch, T.I. and Behnke, B.J., 2024. Pulmonary hypertension impairs vasomotor function in rat diaphragm arterioles. Microvascular Research, 154, p.104686.
Schulze, K.M., Horn, A.G., Weber, R.E., Behnke, B.J., Poole, D.C. and Musch, T.I., 2023. Pulmonary hypertension alters blood flow distribution and impairs the hyperemic response in the rat diaphragm. Frontiers in Physiology, 14, p.1281715.
Schulze, K.M., Weber, R.E., Horn, A.G., Colburn, T.D., Ade, C.J., Poole, D.C. and Musch, T.I., 2022. Effects of pulmonary hypertension on microcirculatory hemodynamics in rat skeletal muscle. Microvascular research, 141, p.104334.
Schulze, K.M., Weber, R.E., Colburn, T.D., Horn, A.G., Ade, C.J., Hsu, W.W., Poole, D.C. and Musch, T.I., 2021. The effects of pulmonary hypertension on skeletal muscle oxygen pressures in contracting rat spinotrapezius muscle. Experimental physiology, 106(10), pp.2070-2082.
andrew horn
Email: hornandrew1621@gmail.com
Research Interests:
My research interests lie within the microcirculation and the vascular control mechanisms that govern tissue hemodynamics, and how these mechanisms are impacted by disease and advancing age. My previous work has focused primarily on the diaphragm, a highly specialized skeletal muscle, and the plasticity of its vasculature in rodent models of prolonged diaphragm inactivity, heart failure, and old age.
Selected Publications:
Horn AG, Schulze KM, Muller-Delp J, Poole DC, Behnke BJ. Effects of aging on diaphragm hyperemia and blood flow distribution in male and female Fischer 344 rats. Am J Physiol Reg Integ Comp Physiol, 327(3), R328-337, 2024.
Horn AG, Kunkel ON, Schulze KM, Baumfalk DR, Weber RE, Poole DC, Behnke BJ. Supplemental oxygen administration during mechanical ventilation reduces diaphragmatic blood flow and oxygen delivery. J Appl Physiol. 132(5):1190-1200, 2022.
Horn AG, Schulze KM, Weber RE, Barstow TJ, Musch TI, Poole DC, Behnke BJ. Post-occlusive reactive hyperemia and skeletal muscle capillary hemodynamics. Microvasc Res. 140: e104283, 2022.
Horn AG, Davis RT 3rd, Baumfalk DR, Kunkel ON, Bruells CS, McCullough DJ, Opoku-Acheampong AB, Poole DC, Behnke BJ. Impaired diaphragm resistance vessel vasodilation with prolonged mechanical ventilation. J Appl Physiol. 127(2):423-431, 2019.
DENISSE GABRIELA MORENO
Email: denissegabrielam@gmail.com
Research Interests:
Selected Publications: