2014 Publications

Donato AJ, Lesniewski LA, Walker AE, Morgan RG. Molecular mechanisms of age-related endothelial dysfunction (Invited Review) J. MOL. & CELL. CARDIOLOGY (In Press)

Walker AE, Henson GD, Reihl KD, Dobson PS, Nielson EI, Ling J, Li DY, Lesniewski LA, Donato AJ.Impaired cerebral artery endothelial function in a mouse model of greater large artery stiffness J. PHYSIOL. (London) (In Press)

Frech T, AE Walker, Barrett-O’Keefe Z, Richardson RS Wray DW, Donato AJ. Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction. CLIN. REUMATOLOGY  (In Press)

Gibson CC, Zhu W, Davis C, Bowman-Kirigin J, Chan A, Ling J, Walker AE, Giotre L, Monache S, Retta S, Shui YY, Grossman A, Thomas K, Donato AJ, Lesniewski LA,Whitehead KJ, Li DY. Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation. CIRCULATION (In Press)

Gano LB, Donato AJ, Pasha HM, Hearon CM, Sindler AL, Seals DR. The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production and inflammation with aging in mice. AM. J. PHYSIOL. HEART and CIRC. (In Press)

Barrett-O’Keefe Z, Ives SJ, Trinity JD, Morgan G, Rossman MJ, Donato AJ, Runnels S, Morgan DE, Gmelch BS, Bledsoe AD, Richardson RS, Wray DW. Endothelin-A (ETA)-mediated vasoconstriction during exercise with advancing age. J. GERONTOL. BIOL. MED. SCI. (In Press)

Venturelli M*, Morgan RG*, Donato AJ, Reese V, Bottura R, Tarperi C, Milanese C, Schena F, Reggiani C, Naro F, Cawthon RM,  Richardson RS. Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age. CLINICAL SCIENCE 127: 415-421. 2014  *Equal Contribution

Henson GD, Walker AE, Reihl KD, Donato AJ, Lesniewski LA (2014). Dichotomous mechanisms of aortic stiffening in high-fat diet fed young and old B6D2F1 mice. Physiol Rep, 2(3), e00268.

Lesniewski LA*, Donato AJ*, Stuart D, Walker AE, Henson G, Sorensen L, Li D, Kohan DE (2014). Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development.LID – S0024-3205(14)00004-6 [pii]LID – 10.1016/j.lfs.2013.12.209 [doi]. Life Sci. *Equal ContributionMorgan RG, Ives SJ, Walker AE, Cawthon RM, Andtbacka RH, Noyes D, Lesniewski LA, Richardson RS, Donato AJ (2014). Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping. J Hypertens, 32(6), 1293-9.Donato AJ, Henson GD, Hart CR, Layec G, Trinity JD, Bramwell RC, Enz RA, Morgan RG, Reihl KD, Hazra S, Walker AE, Richardson RS, Lesniewski LA (2014). The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction. J Physiol, 592(Pt 18), 4083-96.