Click here for Grant Henson’s CV
VA Med.Center, SLC
GRECC Bldg 2 Rm 1C10
500 Foothill Drive
Salt Lake City, UT 84148
Office 801-582-1565 Ext 4334
My primary research focus is vascular aging, particularly the mechanisms contributing to the endothelial dysfunction we observe in older populations. Specifically, I am interested in the interplay between the adipose tissue vasculature and adipose tissue function per se and how these functional phenotypes affect whole body metabolism. A typical “Western” lifestyle, including a diet high in saturated fats and/or a sedentary lifestyle, may induce premature dysfunction in the vasculature, the adipose or both, potentially exacerbating any age-associated phenotype observed in these tissues. Therefore my secondary research focus is to elucidate the mechanisms by which aging and aging in combination with high fat diet contribute to the functional capacity of the adipose tissue vasculature and the adipose tissue per se as well as to investigate novel interventions to prevent or treat the observed dysfunction.
LaRocca TJ, Hearon CM, Henson GD, Seals DR. Mitochondrial quality control and age-associated arterial stiffening. Exp Geronto 58C: 78-82. 2014.
Donato AJ, Henson GD, Hard CR, Layec G, Trinity JD, Bramwell RC, Enz RA, Morgan RG, Reihl KD, Hazra S, Walker AE, Richardson RS, Lesniewski LA. The impact of aging on adipose structure, function, and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction. J Physiol 592(Pt 18): 4083-96. 2014.
Henson GD, Donato AJ, Walker AE, Reihl KD, Lesniewski LA. Dichotomous mechanisms of aortic stiffening in high fat diet fed young and old B6D2F1 mice. Physiological Reports 2(3): 2014.
Donato AJ, Lesniewski LA, Stuart D, Walker AE, Henson GD, Sorensen L, Li D, Kohan DE. Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development. Life Sci. E-pub ahead of print.
Walker AE, Henson GD, Reihl KD, Nielson EI, Morgan RG, Lesniewski LA, Donato AJ. Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries. AGE. 36:559-569. 2014
Donato AJ, Walker AE, Magerko KA, Bramwell RC, Black AD, Henson GD, Lawson BR, Lesniewski LA, Seals DR. Life-Long Caloric Restriction Reduces Oxidative Stress and Preserves Nitric Oxide Bioavailability and Function in Arteries of Old Mice. AGING CELL12(5): 772-83, 2013.
LaRocca TJ, Henson GD, Thorburn A, Sindler AL, Pierce GL, Seals DR. Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol (590): 3305-16, 2012.
Donato AJ, Henson GD, Morgan RG, Enz RA, Walker AE, Lesniewski LA. TNF-α Impairs Endothelial Function in Adipose Tissue Resistance Arteries of Mice with Diet Induced Obesity. Am J Physiol Heart Circ Physiol. 303: H672 – H679, 2012.
Lesniewski LA, Durrant JR, Connel ML, Henson GD, Black AD, Donato AJ, Seals DR. Aerobic exercise reverses arterial inflammation with aging in mice. Am J Physiol Heart Circ Physiol 301(3):H1025-32, 2011.